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Propoxyphene, norpropoxyphene (important metabolite), and acetaminophen are excreted in human milk. Posted reports of nursing moms employing propoxyphene detected no adverse consequences in nursing infants. Based on a examine of 6 mom-toddler pairs, an solely breastfed toddler receives approximately two% of your maternal body weight-modified dose. Norpropoxyphene is renally excreted and renal clearance is lower in neonates than in Grownups.
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Propoxyphene is metabolized primarily through the human cytochrome P450 3A4 isoenzyme procedure (CYP3A4), as a result probable interactions may possibly occur when propoxyphene is administered concurrently with agents that affect CYP3A4 exercise.
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Anticholinergics: The onset of acetaminophen result could possibly be delayed or reduced slightly, but the final word pharmacological effect is not substantially affected by anticholinergics.
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